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KMID : 0545120040140030628
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Journal of Microbiology and Biotechnology
2004 Volume.14 No. 3 p.628 ~ p.630
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Antitumor Activity of Peptide Fraction from Traditional Korean Soy Sauce
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Lee HJ
Lee KW/Kim KH/Kim HK/Lee HJ
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Abstract
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Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dosedependent antiproliferative effect on P388D1 mouse lymphoma F9 mouse teratocarcinoma and DLD-1 human colon cancer cells with IC50 values of 11 50 and 50 mg/ml respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice orally administered with 80 and 200 mg/kg/day of SSPs was inhibited 10.3% and 52.4% respectively and survival days increased by 11.9% and 22.1% respectively compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.
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